EPHYSCIENCE team has developed the first quantitative method to assay progerin and has demonstrated its increased expression in mature skin fibroblasts.
VERDY C., BRANKA JE, MEKIDECHE N.
Quantitative assessment of lactate and progerin production in normal human cutaneous cells during normal ageing: effect of an Alaria esculenta extract.
Int. J. Cosmet. Sci. 33, 462-466, 2011

EPHYSCIENCE team has developed an original quantitative assay of Pmel 17 to get a rapid and pertinent method to assay mélanosomes’ transfer from melanocytes to keratinocytes.
VERDY C., BRANKA JE, MEKIDECHE N.
Melanosome transfer evaluation by quantitative measurement of Pmel 17 in human normal melanocyte-keratinocyte co-cultures: effect of an Alaria esculenta extract.
J. Cosmet. Sci. 63, 197-203, 2012

EPHYSCIENCE team has developed an ELISA assay for TAUT quantitation in young and aged keratinocytes.
Clotilde VERDY, Jean-Eric BRANKA, Luc LEFEUVRE
Modulation of Sodium-Dependent Transporters Expression in Normal Human Keratinocytes by a Sodium Rich Isotonic Thermal Water.
J. Chem. Dermatol. Sci. Appl. 2, 254-262, 2012

EPHYSCIENCE team has developed an ELISA assay for SVCT1 quantitation in young and aged keratinocytes.
Clotilde VERDY, Jean-Eric BRANKA, Luc LEFEUVRE
Modulation of Sodium-Dependent Transporters Expression in Normal Human Keratinocytes by a Sodium Rich Isotonic Thermal Water.
J. Chem. Dermatol. Sci. Appl. 2, 254-262, 2012

EPHYSCIENCE team has developed a model for demonstrating the effect of active compounds on melanogenesis through an action on fibroblast DKK-1 production.
The DKK-1 produced by the fibroblasts binds to the WNT receptor at the melanocytes surface and then modulates the melanin production.
⇒ A relation between fibroblast and melanocyte : A new message in the whitening field
⇒ A physiological regulation